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Glucose transporter 4 activity

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For more information, log on to-http://shomusbiology.weebly.com/Download the study materials here-http://shomusbiology.weebly.com/bio-materials.htmlGlucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Because glucose is a vital source of energy for all life these transporters are present in all phyla. The GLUT or SLC2A family are a protein family that is found in most mammalian cells.GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT proteins transport glucose and related hexoses according to a model of alternate conformation,[5][6][7] which predicts that the transporter exposes a single substrate binding site toward either the outside or the inside of the cell. Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11;[8] also, the QLS motif located in the seventh transmembrane segment could be involved in the selection and affinity of transported substrate.[9][10]GLUT 4 is found in adipose tissues and striated muscle (skeletal muscle and cardiac muscle). It is the insulin-regulated glucose transporter. Responsible for insulin-regulated glucose storage. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.Link- http://en.wikipedia.org/wiki/Main_Page

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